Effects of TNF- and IFN- on Nitric Oxide-Induced Neurotoxicity in the Mouse Brain
نویسندگان
چکیده
منابع مشابه
Effects of co-administration of ghrelin agonist (GHRP-2) and GH on TNF-α, IL-6 and iNOS gene expression induced by LPS in the mouse brain
The aim of this study was to examine the anti-inflammatory effects of co-administration of growthhormone-releasing peptide-2 (GHRP-2) and growth hormone (GH) on tumor necrosis factor-α (TNF-α),interleukin-6 (IL-6) and inducible nitric oxide synthase (iNOS) gene expression induced by LPS in the mousebrain. Thirty-five male NMRI mice (25±5 g) were injected through the mouse tail vein with saline,...
متن کاملFIVE ALPHA DIHYDROTESTOSTERONE (5α-DHT) MAY MODULATE NITRIC OXIDE RELEASE VIA ENDOGENOU S CYTOKINES IN PERITONEAL MA CROPHA GES OF NZB/BALBc MICE
Recent studies have established that sex hormones directly or indirectly affect T and B cells and macrophages by manipulating the production of cytokines. In this study the possibility of the effect of 5a-DHT on macrophage (MΦ) nitric oxide (NO) release via interleukin-l, 6 (lL-1β, IL-6) or tumor necrosis factor-a (TNFα) was investigated. The endogenous cytokines IL-1β, IL-6 and TNF-α were ...
متن کاملAnti-inflammatory Effect of Ethanolic Extract of Euphorbia myrsinites in Lipopolysaccharide-induced Septic Shock in Mice
Background and purpose: Many herbs including Euphorbia have immunomodulatory properties. The aim of this study was to evaluate the immunomodulatory effects of the ethanolic extract of E.myrsinites. Materials and methods: In this experimental study, 40 Swiss albino male mice were randomly divided into 4 groups. Group A included healthy mice, group B was induced by lipopolysaccharide (LPS), grou...
متن کاملبررسی اثرات محافظتی اداراون بر کاهش سمیت کلیوی و عصبی ناشی از مواجهه حاد با دیازینون
Background and purpose: Diazinon (Dz) is a widely used insecticide. It can cause nephrotoxicity and neurotoxicity by induction of oxidative stress. Edaravone is a drug with antioxidant effect that is used in treatment of acute infraction disorders. In this study we used edaravone for ameliorating diazinon induced kidney and brain damage. Materials and methods: Twenty four male Wistar rats were...
متن کاملP-90: The Effect of Nitric Oxide on Mouse Oocyte in Vitro Maturation in Two and Three Dimensional Conditions
Background: In vitro culture of ovarian follicles may preserve fertility in women with premature ovarian failure due to cancer .It seems that creation a condition that could maintain cellular communications and supports growth of follicles to produce mature oocytes appear to be essential. Nitric oxide (NO) has been recently shown to act with a dual action in mouse oocyte meiotic maturation depe...
متن کامل